Dydrogesterone: What It Is and How People Use It
Dydrogesterone is a synthetic form of progesterone that doctors prescribe for several women’s health issues. You might know it by brand names like Duphaston. It works like natural progesterone in the body but is easier to take by mouth and often causes fewer androgenic side effects.
When doctors recommend dydrogesterone
People get dydrogesterone for things like irregular periods, heavy or painful bleeding, luteal phase defects, and to support early pregnancy in cases of threatened or recurrent miscarriage. It’s also used in some hormone replacement therapy regimens. Dydrogesterone is not a contraceptive — it won’t prevent pregnancy.
How it’s taken
Typical doses range from 10 mg once daily to 10 mg two or three times a day, depending on the condition. For luteal support, many prescribers use 10 mg twice daily for part of the cycle. For threatened miscarriage, some protocols start with 10 mg two or three times daily for a short period. Always follow the exact dosing your clinician gives you.
What to expect and common side effects
Most people tolerate dydrogesterone well. Common side effects include breast tenderness, nausea, headache, and mild mood changes. Spotting or irregular bleeding can happen during the first treatment cycles. If you get severe abdominal pain, jaundice, or signs of an allergic reaction, stop the drug and seek medical care right away.
Safety notes and interactions
Dydrogesterone is generally safe but you should tell your doctor about liver disease, unexplained vaginal bleeding, or a history of blood clots. It has fewer interactions than some hormones, but always list current meds and supplements. If you’re on anticonvulsants or strong enzyme inducers, dosing or choice of drug may need review.
Evidence and real-world use
Clinical trials and meta-analyses have looked at dydrogesterone for luteal support and prevention of miscarriage. Some studies show a benefit, especially for women with a history of recurrent miscarriage. Talk to your doctor about how the research applies to your situation; individual factors matter.
Practical tips for users
Take it with or after food to reduce stomach upset. Keep a pill diary if you take it multiple times daily. Don’t stop abruptly without checking with your provider — they’ll tell you when to taper or stop. If you’re trying to get pregnant or already pregnant, make sure your obstetrician knows all medications you use.
When to call your doctor
Call your healthcare provider for heavy bleeding, severe headache, vision changes, calf pain or swelling, yellowing skin, or any new worrying symptom. Also contact them if you miss several doses — they’ll advise next steps.
Want more info?
If you need plain-language summaries of studies or dosing for a specific situation, ask your doctor or pharmacist. They can give guidance tailored to your health and local prescribing practices.
Remember, brand names and availability vary by country. Don’t rely on internet sources alone — use them to prepare questions, then discuss options and risks with a clinician who knows your full medical history today.
